Improving lung cancer screening programs
The results of the UK Lung Screening Trial were recently published in Lancet Regional Health Europe, and the meta-analysis indicated a significant reduction in lung cancer mortality in identified high-risk groups.
In this video, courtesy of VJHemOnc, David Baldwin, MD, Nottingham University Hospitals, England, describes his research evaluating different multivariate risk models that are used to define eligibility for lung cancer screening.
Here is a transcript of what he said:
In the UK we really want to make sure we target the screening intervention to the group that will benefit the most. And this is a difficult area because in fact, at the moment, the current state of research is not entirely clear on how you should do it.
In our Targeted Lung Health Check program, we chose to use two multivariate models to allow people to participate in the program. So this is version 2 of the Liverpool Lung project (LLPv2) and PLCOM2012, either of these models can enter the program. And then other people are unfortunately not eligible. Then there are a number of other exclusion criteria that we have applied to try to exclude people who might not benefit from it.
But what we really need to know, we really need to know if these models are really the most effective in selecting the right people for screening in terms of detecting cancer at any stage, which can then be cured. And this is needed for further research.
In the UK we are also very fortunate to have a very detailed primary care record, which allows us to identify the population of smokers. We can thus avoid contacting a large part of the population who currently would never benefit from screening. But we should also try to develop multivariate models that could be applied to this population to see if there are people we could exclude more – so as not to bother them with something that just spotted them and will not benefit them. not.
It is therefore a source of ongoing research, an area that is still quite fascinating. No doubt this will improve the effectiveness of the intervention.